Bozena Michniak, Director of the LDD
Bozena Michniak, Ph.D.
Director of the Laboratory for Drug Delivery, NJCBM
Professor of Pharmaceutics
Ernest Mario School of Pharmacy
Dr. Michniak-Kohn’s main research focus lies in the area of topical and transdermal drug delivery. Her group is involved in the design and testing of novel dermal penetration enhancer and retardant compounds, investigation of their mechanisms of action and transport through the skin layers, molecular and computational modeling of percutaneous absorption as well as optimization and testing of topical and transdermal formulations. Studies involve novel carrier systems such as nanospheres and investigation of skin transport pathways using confocal microscopy, SEM, TEM, Raman & FTIR. Physical drug delivery enhancement techniques are also being studied such as iontophoresis and the use of microneedles.
Biography:
Representative Recent Publications:
1) Asbill, C.A., Kim, N., El-Kattan, A., Creek, K., Wertz, P., Michniak, B.B. Evaluation of a human bioengineered skin equivalent for drug permeation studies. Pharmaceutical Research, 2000, 17 (9), 1092-1097.
2) Michniak, B.B. Evaluation of derivatives of 3-(2-oxo-1-pyrrolidine) hexahydro-1H-azepine-2-one as dermal penetration enhancers: side chain length variation and molecular modeling. Journal of Controlled Release, 2001, 73,183-196.
3) El-Kattan, A.F., Asbill, C.S., Kim, N., Michniak, B.B. The effect of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities. International Journal of Pharmaceutics, 2001, 215, 229-240.
4) Wang, Y., Fan, Q., Song, Y., Michniak, B. Effect of fatty acids and iontophoresis on the delivery of midodrine hydrochloride and structure of human skin. Pharm. Research 2003, 20 (10), 1612-1618.
5) Al-Khalili, M., Meidan, V., Michniak, B. Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin. AAPS Pharm. Sci., 2003,5 (2), no pages, article 14 at http://www.pharmsci.org.
6) Meidan, V., Al-Khalili, M., Michniak, B. Enhanced iontophoretic delivery of buspirone hydrochloride across human skin using chemical enhancers. Int. J. Pharm., 2003, 264,73-83.
7) Bourke, S., Al-Khalili, M., Michniak, B., Kohn, J., Poole-Warren, L. Protein drug release from photocrosslinked poly(vinyl alcohol) hydrogels. AAPS PharmSci, 2003 ; 5 (4) Article 33 (http://www.aapspharmsci.org) 11 pages.
8) Djordevic, J., Michniak, B., Uhrich, K.E. Amphiphilic star-like macromolecules as novel carriers for topical delivery of non-steroidal anti-inflammatory drugs. AAPS PharmSci , 2003; 5 (4) Article 26 (http://www.pharmsci.org). pp. 256-267.
9) Song, Y., Wang, Y., Thakur, R., Meidan, V.M., Michniak, B. Mucosal Drug delivery: Membranes, Mechanisms and Applications. Critical Reviews in Therapeutic Drug Carrier Systems, 2004, 21 (3), 195-256.
10) Fan, Q., Sirkar, K.K., Wang,Y. and Michniak, B.B. In vitro delivery of doxycycline hydrochloride based on a porous membrane-based aqueous-organic partitioning system. Journal of Controlled Release, 2004, 98, 355-365.
11) Wang, Y., Thakur, R., Fan, Q., Michniak, B.B. Transdermal iontophoresis: Combination strategies to improve transdermal iontophoretic drug delivery. European J. of Pharmaceutics & Biopharmaceutics , 2005, 60, 179-191.
12) Pugh, W.J., Wong, R., Falson, F., Michniak, B.B. Moss, G.P. Discriminant analysis as a toll to identify compounds with potential as transdermal enhancers. Journal of Controlled Release. J. Pharm. Pharmacol., 2005, 57 (11), 1389-96.
13) Song, Y., Xiao, C., Mendelsohn, R., Zheng, T., Strekowski, L., Michniak, B.B. Investigation of Iminosulfuranes as novel transdermal penetration enhancers: enhancement activity and cytotoxicity. Pharm. Research (2005), 22 (11), 1918-1925.
14) Barrow, D.J., Chandrasekaran, S., Heerklotz, H.H., Henary, M.M., Michniak, B.B., Nguyen, P.M. Song, Y., Smith, J.C., Strekowski, L. Mechanistic studies on percutaneous penetration enhancement by N-(4-halobenzoyl)-S,S,-dimethyliminosulfuranes. Journal of Lipid Research (2005), 46, 2192-2201.
15) Meidan, V., Bonner, M.C. and Michniak, B.B. Transfollicular drug delivery: is it a reality? Int. Journal of Pharmaceutics, (2005), 306, 1-14.
16) Simon, L., Weltner, A.N., Wang, Y., Michniak, B. A parametric study of iontophoretic transdermal drug delivery systems. Journal of Membrane Sciences, (2006), 278, 124-132.
17) Goyal, A., Mandapuram, S., Michniak, B., Simon, L. Application of orthogonal collocation and regression techniques for recovering parameters of a two-pathway transdermal drug delivery model. Computers & Chemical Engineering, (2007), 31, 107-120.
18) Pensack, R.D., Michniak, B.B., Moore, D., Mendelsohn, R. I.R. kinetic/structural studies of barrier reformation in intact stratum corneum following thermal perturbation. Applied Spectroscopy, (2006), 60 (12), 1399-1404. Publication received the 2007 Megger Award from the Society of Applied Spectroscopy.
Professor of Pharmaceutics
Ernest Mario School of Pharmacy
Dr. Michniak-Kohn’s main research focus lies in the area of topical and transdermal drug delivery. Her group is involved in the design and testing of novel dermal penetration enhancer and retardant compounds, investigation of their mechanisms of action and transport through the skin layers, molecular and computational modeling of percutaneous absorption as well as optimization and testing of topical and transdermal formulations. Studies involve novel carrier systems such as nanospheres and investigation of skin transport pathways using confocal microscopy, SEM, TEM, Raman & FTIR. Physical drug delivery enhancement techniques are also being studied such as iontophoresis and the use of microneedles.
Several projects involve a tissue engineered full-thickness human skin model which has been shown to possess similar drug permeability to human skin. Projects include evaluation of correlations between the drug permeability, stratum corneum lipid composition/organization, growth media composition, immunohistochemistry, and morphology and gross structure of the bioengineered skin. In addition, a novel polymer dermal scaffold is being tested in the model to improve its mechanical strength. Additional studies involve the effects of protective barrier creams on the penetration of chemical warfare agent mimics using various skin models.
Part of the work includes in vivo pharmacokinetic & metabolic studies with drugs administered by several routes (topical, intravenous-infusion, bolus, and oral). In addition, the group is part of the $15M Rutgers NSF Engineering Research Center examining the scientific foundation, based on a predictive understanding of structure-function-performance relationships, for the optimal design of structured organic composites with advanced functionality.
Part of the work includes in vivo pharmacokinetic & metabolic studies with drugs administered by several routes (topical, intravenous-infusion, bolus, and oral). In addition, the group is part of the $15M Rutgers NSF Engineering Research Center examining the scientific foundation, based on a predictive understanding of structure-function-performance relationships, for the optimal design of structured organic composites with advanced functionality.
Biography:
Bozena B. Michniak-Kohn joined the Ernest Mario School of Pharmacy as Associate Professor of Pharmaceutics (with tenure) in 2005 and is Director of the Laboratory for Drug Delivery of the NJ Center for Biomaterials (NJCBM), as well as Project Leader, FDA Liaison and Steering Committee Member of the $15M NSF Engineering Research Center (ERC). Previously (2000-2005) she was at the Dept. of Pharmacology & Physiology, University of Medicine and Dentistry of NJ- NJ Medical School (Newark) & was Director of the Laboratory for Drug Delivery for NJCBM-Newark. She obtained her Ph.D. in Pharmacology in 1980 from Leicester Polytechnic, Leicester, U.K now renamed the DeMontfort University. Postdoctoral experience was gained with Profs. N. Bodor (University of Florida) and B. Barry (University of Bradford, U.K). She returned in 1986 to the U.S. as Assistant Professor, College of Pharmacy, University of South Carolina-USC, Columbia SC. In 1998 she became tenured full Professor and Director of the Transdermal and Topical Drug Delivery Laboratory at USC.
Dr. Michniak has directed over 20 Ph.D. students, 6 Masters students, and 250+ undergraduates and the work resulted in over 300 abstracts, 3 patent applications, 25 book chapters, and more than 85 papers. From 1995 to 2005 she served as reviewer on the NIH Study Section “Drug Development and Delivery” SBIR/STTR, IRG “Biophysics and Chemistry” and in 2002 she became Chair of this section. She is a reviewer on NIH Study Sections “Gene and Drug Delivery” as well as the Bioengineering Research Partnership Grants (PAR-99-009) and the U.S. Civilian Research and Development Foundation. She has organized and chaired many symposia and workshops for the American Association of Pharmaceutical Scientists (AAPS) and was the 2001 Chair of the Dermatopharmaceutics Focus Group. She was Abstract Screening Chair (2000) and Programming Chair (2004) for the Pharmaceutics and Drug Delivery (PDD) section. She was the 2005 Chair of the AAPS PDD section. She now serves as the 2007 Chair of the AAPS Student and Post Doc Outreach and Development Committee (SPOD). Dr. Michniak also serves as the U.S. Editor of the Controlled Release Society Newsletter. She is a reviewer for over a dozen pharmaceutical and drug delivery journals.
Dr. Michniak has directed over 20 Ph.D. students, 6 Masters students, and 250+ undergraduates and the work resulted in over 300 abstracts, 3 patent applications, 25 book chapters, and more than 85 papers. From 1995 to 2005 she served as reviewer on the NIH Study Section “Drug Development and Delivery” SBIR/STTR, IRG “Biophysics and Chemistry” and in 2002 she became Chair of this section. She is a reviewer on NIH Study Sections “Gene and Drug Delivery” as well as the Bioengineering Research Partnership Grants (PAR-99-009) and the U.S. Civilian Research and Development Foundation. She has organized and chaired many symposia and workshops for the American Association of Pharmaceutical Scientists (AAPS) and was the 2001 Chair of the Dermatopharmaceutics Focus Group. She was Abstract Screening Chair (2000) and Programming Chair (2004) for the Pharmaceutics and Drug Delivery (PDD) section. She was the 2005 Chair of the AAPS PDD section. She now serves as the 2007 Chair of the AAPS Student and Post Doc Outreach and Development Committee (SPOD). Dr. Michniak also serves as the U.S. Editor of the Controlled Release Society Newsletter. She is a reviewer for over a dozen pharmaceutical and drug delivery journals.
Representative Recent Publications:
1) Asbill, C.A., Kim, N., El-Kattan, A., Creek, K., Wertz, P., Michniak, B.B. Evaluation of a human bioengineered skin equivalent for drug permeation studies. Pharmaceutical Research, 2000, 17 (9), 1092-1097.
2) Michniak, B.B. Evaluation of derivatives of 3-(2-oxo-1-pyrrolidine) hexahydro-1H-azepine-2-one as dermal penetration enhancers: side chain length variation and molecular modeling. Journal of Controlled Release, 2001, 73,183-196.
3) El-Kattan, A.F., Asbill, C.S., Kim, N., Michniak, B.B. The effect of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities. International Journal of Pharmaceutics, 2001, 215, 229-240.
4) Wang, Y., Fan, Q., Song, Y., Michniak, B. Effect of fatty acids and iontophoresis on the delivery of midodrine hydrochloride and structure of human skin. Pharm. Research 2003, 20 (10), 1612-1618.
5) Al-Khalili, M., Meidan, V., Michniak, B. Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin. AAPS Pharm. Sci., 2003,5 (2), no pages, article 14 at http://www.pharmsci.org.
6) Meidan, V., Al-Khalili, M., Michniak, B. Enhanced iontophoretic delivery of buspirone hydrochloride across human skin using chemical enhancers. Int. J. Pharm., 2003, 264,73-83.
7) Bourke, S., Al-Khalili, M., Michniak, B., Kohn, J., Poole-Warren, L. Protein drug release from photocrosslinked poly(vinyl alcohol) hydrogels. AAPS PharmSci, 2003 ; 5 (4) Article 33 (http://www.aapspharmsci.org) 11 pages.
8) Djordevic, J., Michniak, B., Uhrich, K.E. Amphiphilic star-like macromolecules as novel carriers for topical delivery of non-steroidal anti-inflammatory drugs. AAPS PharmSci , 2003; 5 (4) Article 26 (http://www.pharmsci.org). pp. 256-267.
9) Song, Y., Wang, Y., Thakur, R., Meidan, V.M., Michniak, B. Mucosal Drug delivery: Membranes, Mechanisms and Applications. Critical Reviews in Therapeutic Drug Carrier Systems, 2004, 21 (3), 195-256.
10) Fan, Q., Sirkar, K.K., Wang,Y. and Michniak, B.B. In vitro delivery of doxycycline hydrochloride based on a porous membrane-based aqueous-organic partitioning system. Journal of Controlled Release, 2004, 98, 355-365.
11) Wang, Y., Thakur, R., Fan, Q., Michniak, B.B. Transdermal iontophoresis: Combination strategies to improve transdermal iontophoretic drug delivery. European J. of Pharmaceutics & Biopharmaceutics , 2005, 60, 179-191.
12) Pugh, W.J., Wong, R., Falson, F., Michniak, B.B. Moss, G.P. Discriminant analysis as a toll to identify compounds with potential as transdermal enhancers. Journal of Controlled Release. J. Pharm. Pharmacol., 2005, 57 (11), 1389-96.
13) Song, Y., Xiao, C., Mendelsohn, R., Zheng, T., Strekowski, L., Michniak, B.B. Investigation of Iminosulfuranes as novel transdermal penetration enhancers: enhancement activity and cytotoxicity. Pharm. Research (2005), 22 (11), 1918-1925.
14) Barrow, D.J., Chandrasekaran, S., Heerklotz, H.H., Henary, M.M., Michniak, B.B., Nguyen, P.M. Song, Y., Smith, J.C., Strekowski, L. Mechanistic studies on percutaneous penetration enhancement by N-(4-halobenzoyl)-S,S,-dimethyliminosulfuranes. Journal of Lipid Research (2005), 46, 2192-2201.
15) Meidan, V., Bonner, M.C. and Michniak, B.B. Transfollicular drug delivery: is it a reality? Int. Journal of Pharmaceutics, (2005), 306, 1-14.
16) Simon, L., Weltner, A.N., Wang, Y., Michniak, B. A parametric study of iontophoretic transdermal drug delivery systems. Journal of Membrane Sciences, (2006), 278, 124-132.
17) Goyal, A., Mandapuram, S., Michniak, B., Simon, L. Application of orthogonal collocation and regression techniques for recovering parameters of a two-pathway transdermal drug delivery model. Computers & Chemical Engineering, (2007), 31, 107-120.
18) Pensack, R.D., Michniak, B.B., Moore, D., Mendelsohn, R. I.R. kinetic/structural studies of barrier reformation in intact stratum corneum following thermal perturbation. Applied Spectroscopy, (2006), 60 (12), 1399-1404. Publication received the 2007 Megger Award from the Society of Applied Spectroscopy.
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